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By simply running a free program, you can help advance research in medicine, clean energy, and materials science.

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How does it work?

By running [email protected] on your computer when you're not using it you will speed up and extend our efforts to design new proteins and to predict their 3-dimensional shapes. Proteins are the molecular machines and building blocks of life. You can read more about protein folding and design here.

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User of the Day

User profile Profile John Cunningham
An amateur IT tragic in Australia, making use of a spare Raspberry Pi and some workplace computers (my own!), trying to help save the world from...

Predictor of the day

Predictor of the day: Congratulations to thirdlight for predicting the lowest energy structure for workunit dt_hallucinate....
22 Oct 2020, 0:00:00 UTC · Discuss

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As of 22 Oct 2020, 15:01:35 UTC [ Scheduler running ]
Total queued jobs: 833,505
In progress: 520,589
Successes last 24h: 281,558
Users (last day ): 1,365,022 (+25)
Hosts (last day ): 4,251,104 (+2367)
Credits last 24h : 56,082,065
Total credits : 114,563,060,570
TeraFLOPS estimate: 560.821


Coronavirus update from David Baker. Thank you all for your contributions!

Here is a short video of David Baker describing some exciting results from de novo designs targeting SARS-Cov-2.

Thank you all for your contributions to this research! Although [email protected] was not directly used for the work described in the publication (link provided below), [email protected] was used for designing relevant scaffolds. Additionally, there are currently many similar designs that bind SARS-Cov-2 and related targets that were engineered using [email protected]

More information is available from the publication, De novo design of picomolar SARS-CoV-2 mini protein inhibitors.

21 Sep 2020, 23:16:33 UTC · Discuss

Switch to using SSL (Secure Socket Layer)

We updated our project to use SSL. The project URL has thus been changed to You can reattach the project using this updated URL at your convenience. Please post any issues regarding this update in the discussion thread.

1 May 2020, 21:25:30 UTC · Discuss

Help in the fight against COVID-19!

With the recent COVID-19 outbreak, [email protected] has been used to predict the structure of proteins important to the disease as well as to produce new, stable mini-proteins to be used as potential therapeutics and diagnostics, like the one displayed above which is bound to part of the SARS-CoV-2 spike protein.

To help our research, we are happy to announce a new application update, and thanks to the help from the Arm development community, including Rex St. John, Dmitry Moskalchuk, David Tischler, Lloyd Watts, and Sahaj Sarup, we are excited to also include the Linux-ARM platform. With this update we will continue to make protein binders to SARS-CoV-2 and related targets using the latest Rosetta source.

Thank you [email protected] volunteers for your continued support to this project. Your CPU hours are used not only to accurately model the structures of important proteins, but to design new ones as well. Let's band together and fight COVID-19!

More details will be available in the Discussion of this news post.

3 Apr 2020, 3:45:24 UTC · Discuss

Designing shape-shifting proteins

Thank you to all [email protected] participants who provided much of the computing used in a recent study published in PNAS describing the design of proteins that adopt more than one well-folded structure, reminiscent of viral fusion proteins.

For more infomation, click here.

19 Mar 2020, 0:47:01 UTC · Discuss

Rosetta's role in fighting coronavirus

Thank you to all [email protected] volunteers for your contributions to help accurately model important coronavirus proteins. The collective computing power that you provide through [email protected] helps academic research groups world wide model important protein structures like these.

From a recent IPD news post:

"We are happy to report that the Rosetta molecular modeling suite was recently used to accurately predict the atomic-scale structure of an important coronavirus protein weeks before it could be measured in the lab. Knowledge gained from studying this viral protein is now being used to guide the design of novel vaccines and antiviral drugs."

Since the release of SARS-CoV-2 genome sequences in late January, a number of important corona virus proteins like the one described above have been modeled on [email protected] volunteer computers. A list of these proteins is provided by the Seattle Structural Genomics Center for Infectious Disease (SSGCID).

24 Feb 2020, 18:19:59 UTC · Discuss

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